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C. M. Science College, Darbhanga

Accredited By NAAC with A Grade
( A Constituent Unit of L. N. Mithila University, Darbhanga )

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Shakir Ahamad

Shakir Ahamad

  • Department: Department of Chemistry

  • Designation: Assistant Professor

  • Email: shakirzaheer111@gmail.com

  • Research Area: Organic Synthesis and Medicinal Chemistry

Resume / Documents

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Dr. Shakir Ahamad was born and raised in Saharanpur, Uttar Pradesh. He completed his Bachelor of Science in Chemistry from Kurukshetra University in 2011 and obtained his M.Sc. in Organic Chemistry from Aligarh Muslim University in 2013. He qualified NET (JRF) and GATE during his postgraduate studies.

He subsequently joined Dr. Kishor Mohanan's research group at CSIR–Central Drug Research Institute (CDRI), Lucknow, where he contributed to the development of novel domino multicomponent reactions using diazo compounds, enabling their safe application in the synthesis of important N-heterocycles. As part of the CSIR–CDRI drug discovery program, he worked on the design, discovery, and preclinical development of small-molecule therapeutics targeting HIV, parasitic diseases, and hyperlipidemia. His research includes the development of aminopyridine-derived PCSK9 inhibitors (CDRI-S-017-0594), aminopropanols as antimalarial agents, and nucleoside analogues for anti-HIV applications.

Later, he worked in Dr. Tejender Thakur’s laboratory at CDRI, focusing on supramolecular formulation strategies for CDK4/6 inhibitors such as palbociclib and ribociclib. He also developed improved solid-state formulations of potent anti-breast cancer lead molecules. In recognition of his contributions, he received CSIR–CDRI Incentive Awards in Chemical Sciences in 2017 and 2020.

From 2019 to 2025, he served as an Assistant Professor in the Department of Chemistry at Aligarh Muslim University.

Since 2025, Dr. Ahamad has been serving as an Assistant Professor in the Department of Chemistry at C.M. Science College, Darbhanga, affiliated with Lalit Narayan Mithila University (LNMU).

His current research interests include the discovery of new chemical entities for the treatment of HIV, malaria, hyperlipidemia, and neurodegenerative disorders, along with organic synthesis, targeted drug delivery, and formulation strategies to improve oral bioavailability. His work has been published in leading peer-reviewed journals such as Journal of Medicinal Chemistry, Drug Discovery Today, Organic Letters, Advanced Synthesis & Catalysis, European Journal of Medicinal Chemistry, Organic & Biomolecular Chemistry, Asian Journal of Organic Chemistry, Chemical Communications, and Bioorganic Chemistry.

Publications

2026

  1. Ahamad, S. et al. Recent Advances in the Total Synthesis of Coumarin-Based Natural Products. Org. Biomol. Chem. (2026), Accepted.
  2. Ahamad, S. et al. Imidazole Scaffolds against Staphylococcus aureus and MRSA: A Medicinal Chemistry Review. Mol. Divers. (2026), Accepted.
  3. Kumar, A.; Akshinthala, P.; Khan, M. H.; Harinath, A.; Kumar, N.; Hussain, M. K.; Ahamad, S. Org. Biomol. Chem. (2026). DOI: 10.1039/D6OB00419A.
  4. Khan, S.; Prinsa; Bano, N.; Ahamad, S. Integrated network pharmacology, molecular docking and MD simulation unravel neuroprotective phytochemicals from Aframomum melegueta targeting microglial neuroinflammation in Alzheimer’s disease. Netw. Model. Anal. Health Inform. Bioinforma. 2026, 15, 87.
  5. Fazal, F.; Dar, N. J.; Ahamad, S.; Khan, S.; Bano, N.; Saha, S.; Nazir, A.; Bhat, S. A. cGAS-STING signaling in Alzheimer’s disease: Microglial mechanisms and therapeutic opportunities. Mol. Aspects Med. 2026, 107, 101444.
  6. Ahamad, S.; Akshinthala, P.; Fazal, F.; Sah, G. K.; Khan, M. H.; Upadhyay, A.; Bhat, S. A.; Hussain, M. K. Small-molecule-based activation of Wnt/β-catenin signaling: An underexplored yet promising strategy for neuroprotection. Bioorg. Chem. (2026), 109540.

2025

  1. Tariq, H.; Khan, S.; Miyan, K.; Qidwai, S. N.; Ahamad, S.; Saquib, M.; Hussain, M. K. Exploring Natural Coumarins in Antiprotozoal Drug Discovery: A Comprehensive Review. Chem. Biodivers. 2025, 22, e01964.
  2. Ahmad, M.; Kumar, A.; Ahamad, S.; Mohanan, K. Harnessing the power of α-diazo compounds: Emerging strategies and expanding applications. Chem. Commun. 2025, 61, 14823–14842.
  3. Ahamad, S.; Saquib, M.; Hussain, M. K.; Bhat, S. A. Targeting Wnt signaling pathway with small-molecule therapeutics for treating osteoporosis. Bioorg. Chem. 2025, 156, 108195.
  4. Khan, K.; Ali, R.; Khatoon, S.; Khan, A.; Kumar, P.; Ahamad, S.; Hussain, M. K. The Groebke–Blackburn–Bienaymé reaction: A powerful tool for generating diverse heterocyclic scaffold libraries in anticancer drug discovery. Eur. J. Med. Chem. 2025, 291, 117629.
  5. Khatoon, S.; Naaz, R.; Khan, U.; Qayyum, F.; Ahmad, S.; Saquib, M.; Hussain, M. K. Natural coumarins as anti-diabetic agents: Mechanisms, therapeutic potential, and amelioration of diabetic complications. Phytomedicine (2025), 157339.
  6. Firoz, H.; Ali, R.; Khan, F. A.; Kakkar, P.; Soni, R. K.; Assiri, M. A.; Ahamad, S.; Saquib, M.; Hussain, M. K. Coumarins as versatile scaffolds: Innovative synthetic strategies for generating diverse heterocyclic libraries in drug discovery. J. Mol. Struct. (2025), 144426.
  7. Ahamad, S.; Saquib, M.; Hussain, M. K. Pseudo-natural products as next-generation scaffolds: Redefining the future of medicinal chemistry. Future Med. Chem. (2025), 1–15.
  8. Khan, S.; Bano, N.; Ahamad, S.; Dar, N. J.; Nazir, A.; Bhat, S. A. Advances in nanotherapeutic strategies for Huntington’s disease: Design, delivery, and neuroprotective mechanisms. Coord. Chem. Rev. 2025, 522, 216206.
  9. Bano, N.; Khan, S.; Ahamad, S.; Dar, N. J.; Alanazi, H. H.; Nazir, A.; Bhat, S. A. Microglial NOX2 as a therapeutic target in traumatic brain injury: Mechanisms, consequences, and potential for neuroprotection. Ageing Res. Rev. (2025), 102735.
  10. Bano, N.; Khan, S.; Ahamad, S.; Dar, N. J.; Alanazi, H. H.; Nazir, A.; Bhat, S. A. Microglial autophagic dysregulation in traumatic brain injury: Molecular insights and therapeutic avenues. ACS Chem. Neurosci. 2025, 16, 543–562.
  11. Khan, N.; Gupta, A.; Ahamad, S.; Hussain, M. K.; Khan, M. U.; Siddiqui, Z. N. Functionalized biochar catalysts: Advancing green chemistry in synthesis of O- and N-heterocycles. Environ. Res. (2025), 122136.
  12. Hussain, M. K.; Ahmad, M.; Khatoon, S.; Khan, M. V.; Azmi, S.; Arshad, M.; Ahamad, S.; Saquib, M. Phytomolecules as Alzheimer’s therapeutics: A comprehensive review. Eur. J. Med. Chem. 2025, 288, 117401.

2024

  1. Therapeutic Targeting of Wnt Antagonists by Small Molecules for Treatment of Osteoporosis. Biochem. Pharmacol. 2024, 230, 116587
  2. Microglia and Gut Microbiota: A Double-Edged Sword in Alzheimer’s Disease. Ageing Res. Rev. 2024, 101, 102515.
  3. State-of-the-art in ZnS-based nanoarchitectures for visible-light photocatalytic degradation of antibiotics and organic dyes. J. Water Process Eng. 2024, 67, 106151.
  4. Unraveling the Puzzle of Therapeutic Peptides: A Promising Frontier in Huntington’s Disease. J. Med. Chem. 2024, 67, 783–815.
  5. Appraisal of folate-functionalized bosutinib cubosomes against hepatic cancer cells: In vitro, in silico, and in vivo pharmacokinetic study. Int. J. Pharm. 2024, 654, 123975.
  6. Excitotoxicity, oxytosis/ferroptosis, and neurodegeneration: Emerging insights into mitochondrial mechanisms. Aging Dis. 2024, DOI: 10.14336/ad.2024.0125-1.
  7. Pseudo-natural products: Expanding chemical and biological space by surpassing natural constraints. Bioorg. Chem. 2024, 150, 107525.
  8. Coumarins as versatile therapeutic phytomolecules: A systematic review. Phytomedicine 2024, 134, 155972.
  9. Unleashing the power of bio-adsorbents: Efficient heavy metal removal for sustainable water purification. J. Water Process Eng. 2024, 64, 105705.
  10. Activated green tamarind pulp (AGTP) as an efficient adsorbent for removal of Pb²⁺, Cu²⁺, Zn²⁺, and Ni²⁺ from contaminated water. J. Water Process Eng. 2024, 59, 105048.
  11. Trifluoromethylnitrone: A versatile building block for synthesizing trifluoromethyl-containing heterocyclic compounds. Org. Biomol. Chem. 2024, 22, 5242.

2023

  1. Synthesis and spectral studies of organotin(IV) dithiocarbamates derived from 2-aminoethyl piperazine: Anticancer and anti-nematode activity. J. Mol. Struct. 2023, 1294, 136462.
  2. A direct silver-catalyzed three-component approach to trifluoromethylated cyanopyrazoles and cyanopyrazolines. Adv. Synth. Catal. 2023, 365, 2218.
  3. An ultrasound-assisted, ionic liquid–molecular iodine synergy driven efficient green synthesis of pyrrolobenzodiazepine–triazole hybrids as potential anticancer agents. Front. Pharmacol. 2023, 14.
  4. The emerging landscape of natural small-molecule therapeutics for Huntington’s disease. Curr. Neuropharmacol. 2023, 21, 867.
  5. Efficient removal of Pb²⁺, Cu²⁺, and Zn²⁺ by waste tea-derived cost-effective bioadsorbent. ChemistrySelect 2023, 8, e202300944.

2022

  1. Recent update on the development of PCSK9 inhibitors for hypercholesterolemia treatment. J. Med. Chem. 2022, 65, 15513.
  2. The emerging landscape of small-molecule therapeutics for the treatment of Huntington’s disease. J. Med. Chem. 2022, 65, 15993–16032.
  3. Development of small-molecule PCSK9 inhibitors for the treatment of hypercholesterolemia. Drug Discov. Today 2022.

2021

  1. Trifluorodiazoethane: A versatile building block to access trifluoromethylated heterocycles. J. Heterocycl. Chem. 2021.
  2. Understanding guest binding in cucurbit[7]uril inclusion complexes of CDK4/6 inhibitors (palbociclib and ribociclib): Combined experimental and computational study. J. Mol. Struct. 2021, 1241, 130637.
  3. Additive-free synthesis of trifluoromethylated spirocyclopropanes and their transformation into trifluoromethylated building blocks. Asian J. Org. Chem. 2021, 10, 1536–1541.
  4. Primed for global coronavirus pandemic: Emerging research and clinical outcome. Eur. J. Med. Chem. 2021, 209, 112862.

2019

  1. Silver-catalyzed three-component route to trifluoromethylated 1,2,3-triazolines using aldehydes, amines, and trifluorodiazoethane. Org. Lett. 2019, 21, 2962.

2018

  1. Metal-free three-component assembly of fully substituted 1,2,3-triazoles. Asian J. Org. Chem. 2018, 7, 1698.
  2. Base-mediated 1,6-conjugate addition reaction of Seyferth–Gilbert reagent to p-quinone methides. Org. Biomol. Chem. 2018, 16, 4623.

2017

  1. Three-component synthesis of 3,4-disubstituted pyrazoles using diazosulfone as a diazomethane surrogate. ChemistrySelect 2017, 2, 11995.

2016

  1. Three-component domino HWE olefination/1,3-dipolar cycloaddition/oxidation strategy for the rapid synthesis of trisubstituted pyrazoles. ChemistrySelect 2016, 1, 5276.
  2. Metal-free three-component domino approach to phosphonylated triazolines and triazoles. Org. Lett. 2016, 18, 280.

2015

  1. Substrate-controlled product selectivity in the reaction of the Bestmann–Ohira reagent with N-unprotected isatin-derived olefins. Org. Biomol. Chem. 2015, 13, 9783.
  2. Domino reaction involving the Bestmann–Ohira reagent and unsaturated aldehydes: Efficient synthesis of functionalized pyrazoles. Org. Biomol. Chem. 2015, 13, 1492.